![]() We performed a systematic review of the literature and a meta-analysis according to the Cochrane Collaboration methodology. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues. Insulin Analogues Versus Human Insulin In Type 1 Diabetes: Direct And Indirect Meta-analyses Of Efficacy And SafetyĪRTICLE Andréia Cristina Conegero Sanches Cassyano Januário Correr Rafael Venson Patrícia Rodrigues Gonçalves Mariana Martins Garcia Mário Sérgio Piantavini Roberto Pontarolo Pharmacy Department, Federal University of Paraná, Curitiba, PR, Brazil ABSTRACT All patients with Diabetes Mellitus (DM) receive insulin therapy. Mean duration on analogue insulin therapy was 19.1 months. 10.12) years, mean diabetes duration 10.8 (S.D. Treatment efficacy was evaluated by HbA1c levels, weight difference and changes in total daily dose (TDD) analogue vs human. We retrospectively included 384 patients, previously treated ≥24 months with human insulins, switched to an analogue insulin for ≥12 months. Methods: This study is realised in real life patients. The aims of our study is to evaluate the efficacy of analogues vs human insulins and differences between various analogue insulin, in type 2 diabetes patients, previously treated with human insulin. ![]() A lot of studies have compared the efficacy of new insulin therapies, but in our country, specialists still have to demonstrate at the institutions the treatment’s efficacy and cost-effectiveness for new insulin analogues. By consistently tracking carbohydrate intake, insulin doses, and blood sugar levels while utilizing principles like the Rule of 500 or 450, you can optimize your I:C ratio and maintain better control of your diabetes.Evaluating Analogue Vs Human Insulin Efficacy In Real Life: Observational Study In Type 2 Albanian Diabetic Patients, Previously Insulin Treatedīackground and aims: Insulin therapy is an important part of diabetes treatment. In conclusion, understanding how to calculate your insulin to carbohydrate ratio is fundamental for effective diabetes management. Remember that the I:C ratio can differ throughout the day, so you may require different ratios for breakfast, lunch, and dinner. Factors such as exercise, stress, illness, and hormonal fluctuations can affect insulin needs be prepared to make adjustments as necessary.ģ. Always consult with your healthcare professional before making any changes to your insulin management plan.Ģ. Regularly reviewing your blood sugar levels and adjusting the I:C ratio accordingly will ensure optimal control.ġ. The calculated I:C ratio serves as a starting point, and adjustments may be required based on your blood sugar levels and overall diabetes management. Step 5: Adjust Your Insulin to Carbohydrate Ratio as Needed This means one unit of insulin would cover 10 grams of carbohydrates in a meal. If your TDD is 50 units, your initial I:C ratio would be: ![]() The Rule of 500 (for those who use rapid-acting analog insulins like Humalog, Novolog, or Apidra) or the Rule of 450 (for those who use Regular insulin) is often applied to calculate an initial I:C ratio. TDD serves as a starting point for determining your I:C ratio. To determine your TDD, add up all the rapid-acting insulin used throughout the day for meals and corrections as well as any basal (long-acting) insulin taken. Step 3: Calculate Your Total Daily Insulin Dose (TDD) Record your carbohydrate consumption and insulin usage for at least one week, paying close attention to pre-meal blood sugar levels and any corrections made due to high or low readings. Step 2: Track Your Carbohydrate Intake and Insulin Dosesīefore calculating your I:C ratio, it’s crucial to have accurate information about your daily carbohydrate intake and insulin doses. Ratios vary from one individual to another and can change over time based on factors such as age, activity level, and metabolic rate. For instance, an I:C ratio of 1:15 means that one unit of insulin covers 15 grams of carbohydrates in a meal. The I:C ratio tells you how many units of insulin are needed to cover a specified number of grams of carbohydrates. Step 1: Understand the Basics of Insulin to Carbohydrate Ratio This article will walk you through the steps to calculate your I:C ratio and provide tips for using this information successfully in managing diabetes. The I:C ratio allows you to determine the appropriate amount of insulin needed to maintain stable blood sugar levels after a meal. Calculating your insulin to carbohydrate (I:C) ratio is an essential skill for managing diabetes effectively.
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